en علوم پایه پزشکی Basic Medical Sciences مروری Review Article <div style="text-align: justify;"><span style="font-size:14px;"><span style="line-height:200%"><span style="font-family:Calibri,sans-serif"><i><span lang="EN-US"><span style="line-height:200%"><span cambria="">Fibrosis</span></span></span></i><span lang="EN-US"><span style="line-height:200%"><span cambria=""> is a common and mostly progressive pathological outcome in various chronic inflammatory disorders. Dermal (skin) fibrosis, which is associated with intense skin lesions, is a result of an uncontrolled healing process in the dermis, particularly disproportionate fibroblast proliferation and extracellular matrix (ECM) production. Animal models are substantial tools in biomedical investigations and have been considerably employed to evaluate miscellaneous features of diseases that cannot be demonstrated otherwise in humans. To date, various skin fibrosis models have been generated, including the transgene and/or genetic models and chemical and drug-induced models. However, genetic models are sophisticated and need access to convoluted methods. Accordingly, the introduction of affordable and easy to generate fibrosis models in the skin is crucial. Here, we aimed to introduce the chemical/drug-induced skin fibrosis animal models to provide an updated list of available approaches. </span></span></span></span></span><br> &nbsp;</span></div> Fibrosis,Models, Animal,Skin,Bleomycin,Hypochlorous Acid,Vinyl Chloride, 69 75 http://goums.ac.ir/jorjanijournal/browse.php?a_code=A-10-452-7&slc_lang=en&sid=1 Mahmoud Mohammadi mahmoudmhmdi@yahoo.com 10031947532846008014 0000000337462201 No Department of biology, Islamic Azad University, Arsanjan branch, Arsanjan, Iran. Leila Kohan leila_kohan@yahoo.com 10031947532846008015 10031947532846008015 No Department of biology, Islamic Azad University, Arsanjan branch, Arsanjan, Iran. Mohsen Saeidi saeedi.m50@gmail.com 10031947532846008016 0000000203996160 Yes Stem Cell Research center, Golestan University of Medical Sciences, Gorgan, Iran. Marie Saghaeian-Jazi marie.saghaeian@goums.ac.ir 10031947532846008017 10031947532846008017 No Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran. Saeed Mohammadi saeed.mohammadi6578@yahoo.com 10031947532846008018 0000000198958468 No Stem Cell Research center, Golestan University of Medical Sciences, Gorgan, Iran.